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  • Kermanshah Biliogy research Center
  • Kermanshah Biliogy research Center
  • Kermanshah Biliogy research Center

Ali Fatahi

 

 

Date Prepared:

February12,2017

Name:

Ali Fattahi

Office Address:

Kermanshah University of Medical Sciences, Kermanshah, Iran

Home Address:

Tiruj Building, Khoram St., Kermanshah, 6714793369, Iran

Work Phone:

+988334276480

Work Email:

Alifattahi@kums.ac.ir

Work FAX:

+988334276493

Place of Birth:

Ardakan, Yazd, Iran

 

Education

 

2003

PharmD                       

Pharmacy

Isfahan University of Medical Science, Isfahan, Iran

2012

PhD

Biomaterials

Isfahan University of Technology,Isfahan, Iran

Appointments at Hospitals/Affiliated Institutions

 

 

 

 

 

Other Professional Positions

 

2015-2016

Head of Pharmaceutical Department

Kermanshah University of Medical science

 

 

 

 

Major Administrative Leadership Positions

 

 

2014-2016

Dean of Educational Pharmacy

Kermanshah University of Medical Sciences

 

Committee Service

2015-

Development of Applied Biotechnology in west of Iran Committee

Kermanshah University of Medical Sciences

 

2015

Member

Professional Societies

 

2003-present

2005-present

2012-present

 

Medical Council, Iran

Iranian Association of Pharmacists

Iranian Association of Pharmaceutical Scientists

Member

Member

Member

Grant Review Activities

 

2015-

Knowledge-Based CompanyReview Committee

Iran Technology and Entrepreneurship Company

 

 

Reviewer

Editorial Activities

 

 

Carbohydrate Polymer

Plus one

Materials Science and Engineering C

International Journal of Nanomedicine

Journal of Bioactive and Compatible Polymers

Pharmacognosy Magazine

Iranian Journal of Pharmaceutical Sciences

 

Honors and Prizes

 

2011

Students award of 2ndNanotoday conference

NanoToday Journal

 

2014

Distinguished researcher

Kermanshah University of Medical Sciences

 

 

Report of Funded and Unfunded Projects

Funding Information

Current

2013-2016

Preparation and Characterization of Tragacanth Microcapsule-Containing beta-pancreatic Cells

 

KUMS/91424

 

PI

 

The major goal of the study is cell therapy for diabetes mellitus

 

2013-present

Producing polymeric micelles using anti-cancer drug-polymer conjugates.

 

KUMS/91199, 93452, 93471

 

PI

 

The major goal of the study is to develop anew generation of polymeric micelles with high drug loading capacity and co-delivery of two or more anticancer drug for combination therapy of cancers.

2013-present

Polymeric electro-spun mats for skin regeneration.

 

KUMS/92268, 93419,

 

PI

 

The major goal of the study is to produce biodegradable polymeric mats containing regenerative compounds (consist of herbal and chemical) and antibiotics for regeneration of burnt skin and diabetics wounds.

 

2014-2016

Fabrication of mono-dispersed PLGA microparticles using a microfluidic chip for drug delivery

 

KUMS/92202, 93303,

 

PI

 

The major goal of the study is to develop reproducible system for industrial production of sustained release form of triptorelin, risperidone, etc.

 

 

 

Report of Local Teaching and Training

Teaching of Students in Courses

 

 

2012-present

Pharmaceutics II (powders and tablets)

Kermanshah University of medical sciences

 

3rd-yearpharmacy students

3-hr sessions per wk for 15 wks, 1semester per year

2012-present

Pharmaceutics IV

Kermanshah University of medical sciences

 

4th-yearpharmacy students

2-hr sessions per wk for 15 wks, 1 semester per year

2012-present

Pharmaceutics V (novel drug delivery systems)

Kermanshah University of medical sciences

 

5th-yearpharmacy students

2-hr sessions per wk for 15 wks, 1 semester per year

2012-present

Polymer in pharmaceutics                           

Kermanshah University of medical sciences

 

5th-yearpharmacy students

2-hr sessions per wk for 15 wks, 1 semester per year

2014-present

Biomaterials       

Kermanshah University of medical sciences,

 

MSc students of Bioelectric

3-hr sessions per wk for 15 wks, 1 semester per year

2015

Materials and systems in nano-biotechnology

Razi university, Kermanshah,3-hr sessions per wk for 15 wks

 

Ph.D. students of nano-biotechnology

 

 

Clinical Supervisory and Training Responsibilities

 

2013-present

Supervising and practical education of pharmacy students at educational pharmacy, KUMS

8 sessions per semester

 

Local Invited Presentations

No presentations below were sponsored by outside entities

 

2007                Cell culture techniques and molecular biology for Biomaterial Students/Workshop

                        Medical University of Isfahan

 

2005

Pharmacology for nurses / Workshop

 

in Fereidunshahr Hospital, Fereidunshahr, Isfahan, Iran

 

2010

Application of Statistic in Biomaterial Researches/ Workshop

 

Isfahan University of Technology, Isfahan, Iran

 

 

2010

Concept of Biocompatibility in Biomaterials / Workshop

 

Isfahan University of Technology

 

2010

Chemistry of nano-drug delivery / Workshop

 

Payame-noor University of Isfahan. Isfahan, Iran

 

                                               

Report of Regional, National and International Invited Teaching and Presentations

Invited Presentations and Courses

Regional

2014-present

Pharmaceutics V (novel drug delivery systems), 2-hr sessions per wk for 15 wks,

 1 semester per year, Yazd University of Medical Sciences,Yazd,Iran

 

 

Report of Clinical Activities and Innovations

Current Licensure and Certification

 

2009-present

Iran's Pharmacy License

Practice Activities

List all clinical activities, both those at Harvard and its affiliates and those outside Harvard, and for each indicate:

 

2003-2005

Hospital Pharmacist

Hajar Hospital, Shahrekord, Iran

6 h per day, 6 days/week

2005

Hospital Pharmacist

Hospital of Feridunshahr, Feridunshahr, Isfahan, Iran

6 h per day, 6 days/week

2003-2007

Pharmacist

Dr. Fattahi Pharmacy, Asgaran, Isfahan, Iran

4 h per day, 6 days/week

 

If you have no current clinical activities, but have practiced in the past you may provide a brief (1-2 sentence) description of those prior activities

 

Report of Technological and Other Scientific Innovations

 

The antimicrobial polymeric scaffold of silk/tragacanth for thetreatment of bone infection.

Iran patent, 83218, filed March 8, 2014

 

One of my MS student and I created an antibacterial silk fibroin/deesterified tragacanth scaffold

Nano-fibers of silk/gelatin containing antibiotic for treatment of infections

Iran patent, 83216, filed January 26, 2014

 

As a part of our research in regenerative mats for skin regeneration, we have produced an antibacterial wound dressing

 

May include a brief, one-sentence description of each role if needed (optional)

 

Report of Scholarship

Publications

 

  1. Sadeghi  Aliabadi H, Ghasemi N, Fatahi A. Cytotoxic effects of Iranian mistletoe extract on a panel of cancer cells. Iranian  J.Pharm. Sci. 2006; 2(3):157-162.
  2. Fattahi A*, Golozar MA, Varshosaz J, Sadeghi HM, Fathi M. Preparation and characterization of micelles of oligomeric chitosan linked to all-trans retinoic acid. Carb. Pol. 2011;78(2):1176-1184.
  3. Sadeghi-Aliabadi H, Aliasgharluo M, Fattahi A, Ghanadian M. In vitro cytotoxic evaluation of some synthesized COX-2 inhibitor derivatives against a panel of human cancer cell lines. RPS. 2013;8(4):299-304.
  4. Fattahi A*, Petrini P, Munarin F, Shokoohinia Y, Golozar MA, Varshosaz J, Tanzi MC. Polysaccharides derived from tragacanth as biocompatible polymers and gels. J. Appl. Polym. Sci. 2013;129(4):2092–2102.  
  5. Fattahi A*, Sadrjavadi K, Golozar MA, Varshosaz J, Fathi MH, Mirmohammad-Sadeghi H. Synthesis and characterization of novel chitosan oligomer-water soluble tragacanth nanoparticles as agene carrier. Carb. Pol. 2013;97:277–283.     
  6. Chakraborty S, Christoforou N, Fattahi A, Herzog RW, Leong KW.  A robust strategy for negative selection of Cre-LoxP recombination-based excision of transgenes in induced Pluripotent Stem Cells. Plos one. 2013;8(5):e64342.
  7. Fattahi A*, Golozar M-A, Varshosaz J. Retinoic Acid-Oligomeric Chitosan Micelles as Novel Gene Delivery Carrier; in Vitro Transfection Study. Journal of Reports in Pharmaceutical Sciences (JRPS). 2013;2(2):36-41.
  8. Mohammadi Gh, Hemati V, Mirzaee Sh, Fattahi A, Adibkia Kh. In vitro and In vivo evaluation of Clarithromycin-Urea solid dispersions prepared by solvent evaporation, electrospraying and freeze drying. Powder technology. 2014;257:168-174.
  9. Shokoohinia Y, Sajjadi SE, Gholamzadeh S, Fattahi A, Behbahani M. Antiviral and cytotoxic evaluation of coumarins fromPrangos ferulacea. Pharm. Biol. 2014;52(12):1543-9.
  10. Tajani B, Tahvilian R, Khazaei S, Javadi KS, Fattahi A*. Preparation and Characterization of Camptothecin Grafted Chitosan Oligosaccharide Nanomicelles. Journal of Reports in Pharmaceutical Sciences (JRPS). 2015;4(1):1-11.
  11. Fattahi A, Asgarshamsi M, Hasanzadeh F, Varshosaz J, Rostami M, Mirian M, et al. Methotrexate-grafted-oligochitosan micelles as drug carriers: synthesis and biological evaluations. Journal of Materials Science: Materials in Medicine. 2015;26(2):1-10.
  12. Nayeri H, Fattahi A, Iranpoor-Mobarakeh M, Nori P. Stabilization of lactoperoxidase by tragacanth-chitosan nano biopolymer. International Journal of Biosciences (IJB). 2015;6(2):418-26.
  13. Sajjadi SE, Jamali M, Shahbazi B, Fattahi A, Shokoohinia Y. Antiproliferative Evaluation of Terpenoids and Terpenoid Coumarins from Ferulago macrocarpa (Fenzl) Boiss. Pharmacognosy Research. 2015; 7(4):322-28.
  14. Shahbazi B, Taghipour M, Rahmani H, Sadr-javadi K, Fattahi A*. Preparation and Characterization of Silk Fibroin/Oligochitosan Nanoparticles for siRNA Delivery. Colloids and Surfaces B: Biointerfaces. 2015; 136:867-77.
  15. Maghsoudi S, Ghorbani F, Ashrafi-Kooshk MR, Fattahi A, Khodarahmi R. Isolation and comparative characterization of α-amylase inhibitor from white kidney bean (Phaseolus Vulgaris): A serious in vitro assessment of the commercial product. Journal of Reports in Pharmaceutical Sciences (JRPS). 2015;4(2):167-76.
  16. Haghighi Pak Z, Abbaspour H, Karimi N, Fattahi A. Eco-Friendly Synthesis and Antimicrobial Activity of Silver Nanoparticles Using Dracocephalum moldavica Seed Extract. Applied Sciences. 2016;6(3):69-78.
  17. Safdari M, Shakiba E, Kiaie SH, Fattahi A*. Preparation and characterization of Ceftazidime loaded electrospun silk fibroin/gelatin mat for wound dressing. Fibers and Polymers. 2016;17(5):744-50.
  18. Abdolmaleki S, Ghadermazi M, Fattahi A, Sheshmani S. Synthesis, characterization, spectral studies and cytotoxic effects of mixed-ligand mono and binuclear copper (II) complexes and their amide ligands. 2016;443:284-98.
  19. Tahvilian R, Tajani B, Sadrjavadi K, Fattahi A*. Preparation and characterization of pH-sensitive camptothecin-cis-aconityl grafted chitosan oligosaccharide nanomicelles. International Journal of Biological Macromolecules. 2016;92:795-802.
  20. Fattahi A, Niyazi F, Shahbazi B, Farzaei MH, Bahrami G. Journal of Evidence-Based Complementary & Alternative Medicine. 2017;22(1):127-33. 
  21. Jafarifar E, Hajialyani M, Akbari M, Rahimi M, Shokoohinia Y, Fattahi A*. Preparation of a reproducible long-acting formulation of risperidone-loaded PLGA microspheres using themicrofluidic method. Pharmaceutical Development and Technology. Accepted (DOI: 10.1080/10837450.2016.1221426).
  22. Mohammadi Gh, Shakeri A, Fattahi A, Mohammadi P, Mikaeili A, Aliabadi A, Adibkia Kh. Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles. Pharmaceutical Research. Accepted (DOI: 10.1007/s11095-016-2062-6).
  23. Ahmadi E, Sadrjavadi K, Mohammadi Gh, Fattahi A*. De-esterified tragacanth microspheres loaded into Eudragit S-100 coated capsules for colon-targeted delivery. Iranian Journal of Pharmaceutical Research (Accepted).
  24. Shakiba E, Khazaee S, Hajalyani M, Astinchap B, Fattahi A*.Preparation and Characterization of Retinoic Acid Loaded Poly (ε-Caprolacton)-Poly (Ethylene glycol)-Poly (ε-Caprolacton) Micelles; an In Vitro Study. Research in Pharmaceutical Sciences. (Accepted)
  25. Abdolmaleki S, Ghadermazi M, Fattahi A, Shokraii S, Alimoradi M, Shahbazi B, Judy Azar AR. Synthesis, crystallographic and spectroscopic studies, evaluation as antimicrobial and anticancer agents of a novel mixed-ligand nickel(II) complex. Journal of Coordination Chemistry. Accepted (DOI: 10.1080/00958972.2017.1293821)

Non-peer reviewed scientific or medical publications/materials in print or other media

 

Book chapter

1.       Fattahi A., Varshosaz J. What are the limitations of chitosan use in non-viral gene delivery and how to overcome them? In: Wang SF, editor. Biocompatible Nanomaterials: Synthesis, Characterization, and application. NOVA publisher; 2010.

Thesis

 

Fattahi A., 2012. Modification of chitosan mediated gene delivery system with retinoic acid and pectin. Ph.D. Thesis, Isfahan University of Technology

 

 

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

 

1.       Alvandimanesh, Davari E, Sadrjavadi K, and Fattahi A. Preparation and characterization of water-soluble tragacanth microcapsules by extrusion method for encapsulation of beta pancreatic cells. CRSI, Tehran, Iran, 2014.

2.       Shahbazi B, MohammadiGh, HossinzadehL, and Fattahi A. Preparation and characterization of siRNA-lipoplex loaded PLGA micro/nanoparticles; an in vitro gene silencing study. CRSI, Tehran, Iran, 2014.

3.       Ahmadi E, and Fattahi A. Preparation and characterization of calcium tragacanth nanoparticles for control release of 5-fluorouracil. CRSI, Tehran, Iran, 2014.

4.       Jafarifar E, NikrayS, ShokoohiniaP, SadrjavadiK, SoleimaniM, and Fattahi A. Effect of Microfluidic Chip Geometry on Morphology and Size of PLGA Microparticles. CRSI, Tehran, Iran, 2014.

5.       KhademianS., and Fattahi A. Preparation and Characterization of Vancomycin Loaded Silk Fibroin Scaffold. CRSI, Tehran, Iran, 2014.

6.       KhazaeiS. TahvilianR, and Fattahi A. Synthesis of poly(ɛ-caprolacton)-poly(ethylene glycol)-poly(ɛ-caprolacton) triblock copolymer,  and preparation and characterization of acid loaded poly(ɛ-caprolacton)-poly(ethylene glycol)-poly(ɛ-caprolacton) micelles. CRSI, Tehran, Iran, 2014.

  1. SadrjavadiK, RahmatiF, TajaniB, TahvilianR, and Fattahi A. Preparation and characterization of Camptothecin grafted chitosan oligosaccharide nanomicelles. CRSI, Tehran, Iran, 2014.
  2. DavariE, AhmadiE, Malek-KhatabiA, and Fattahi A. Sustained release of 5-fluorouracil from chitosan oligosaccharide-water soluble tragacanthcore-shell nanoparticles. CRSI, Tehran, Iran, 2014.
  3. Pajuhan M, FattahiA, AmiriM, and Tahvilian R. CRSI, Tehran, Iran, 2014.
  4. ShokoohiniaP, Jafari-FarE, NikrayS, RahimiM., MohammadiG, and Fattahi A. The Effect ofConcentration of Polymer and Surfactanton theSizeand Size Distribution of PLGA Nano-ParticlesPrepared by Microfluidic Method. CRSI, Tehran, Iran, 2014.
  5. TahvilianR, TajaniB, SadrjavadiK, MostafaieA, and Fattahi A. Preparation and characterization of pH sensitive camptothecin-cis aconityl grafted chitosan oligosaccharide nanomicelles. CRSI, Tehran, Iran, 2014.
  6.  RahmaniH, AstinchapB, and Fattahi A. Preparation of 5-FU Loaded Silk Fibroin Nanoparticles: an in vitro study. CRSI, Tehran, Iran, 2014.
  7. RahmatiF, Shokoohinia Y, and Fattahi A. Synthesis of poly(amino ester) containing alkyne side chain for conjugation of anticancer drugs to the back-bone polymer by click reaction. CRSI, Tehran, Iran, 2014.
  8. SafdariM, and Fattahi A. Preparation and Characterization of CeftazidimeLoadedElectrospunSilkFibroin Mate as Wound Dressing. CRSI, Tehran, Iran, 2014.
  9. NikrayS, JafarifarE, ShokoohiniaP, DavariE, SoleimaniM, and Fattahi A. Fabrication of monodisperse PLGA microparticles using a T-shaped microfluidic device for drug delivery. CRSI, Tehran, Iran, 2014.
  10. TaghipourM, and Fattahi A. Preparation and characterization of siRNA loaded silk fibroin nanoparticles. CRSI, Tehran, Iran, 2014.
  11. Mohammadi Gh, Hemati V, Mirzaee Sh, Fattahi A, Adibkia Kh. In vitro and In vivo evaluation of Clarithromycin-Urea solid dispersions prepared by solvent evaporation, electrospraying and freeze drying. CRSI, Tehran, Iran, 2014.
  12. Fattahi A, Fakhri S, Hosseinzadeh L, SadrJavadi K. Preparation and characterization of porous chitosan/tragacanthic acid hybrid scaffold with the freeze-gelation method. IPSC, Isfahan, Iran, 2012.
  13. Gholamzadeh S, Behbahani M, Fattahi A, Sajjadi SE, Shokoohinia Y. Antiviral evaluation of coumarins from Prangos ferulacea L.(Lindl). IPSC, Isfahan, Iran, 2012.
  14. Fattahi A, Golozar MA, Varshosaz J, Fathi MH,  Sadeghi HM. Preparation and characterization of the novel All Trans Retinoic Acid grafted chitosan oligosaccharide micelles. 2ndNanotoday conference, Hawaii, USA, 2011.
  15. Fattahi A., Pezzoli D., Varshosaz j., Golozar M.A., Mohammad-Sadeghi H.M., Petrini P., Tanzi M.C., Candiani G., Characterization of pectin-coated polyethyleneimine polyplexes as effective gene delivery systems. 23th ESB (European Society of Biomaterials), Tampere, Finland, 2010.
  16. Fattahi A., Petrini P., Munarin F., Golozar M.A., Varshosaz J., Fathi M.A., Tanzi M.C., UV Evaluation of Polyplex/Pectin Micro- and Nano-particles for Gene Therapy. 23th ESB (European Society of Biomaterials), Tampere, Finland, 2010.
  17. Sadeghi-Aliabadi H, Ghasemi N, Fatahi A. Cytotoxic evaluation of Iranian mistletoe extract on a panel of cancer cells. 4th World Congress of cellular and molecular biology, Poitiers, France, October 2005.
  18. Sadeghi-Aliabadi H, Fatahi A, Ghassemi-Dehkordi N, Cytotoxicity of Iranian Mistletoe Extract (IME) on a panel of cancer cells. 3rd International Congress of Health, Environment & natural products. Mashhad, Iran, 2004.

 

Narrative Report

 

 

I received my Pharm D at Isfahan University of Medical Sciences and completed my internship at Hajar Hospital and Feridonshahr Hospital in Iran, andimmediately after graduation from pharmacy school, I established my own pharmacy in Asgaran, Isfahan, Iran.I completed my Ph.D. at theIsfahan University of Technology, Isfahan, Iran. I was also visiting astudent at Polytechnic of Milan and Duke university when I was working on my thesis project, non-viral gene delivery system. My clinical experiences as a pharmacist together with my experiences at different biomedical engineering departments help me to produce a brig between medicine and engineering in fields of my interest; drug delivery and tissue engineering.

Since I have started my activity as an assistant professor at Kermanshah University of Medical Sciences (KUMS), I have established Tissue Engineering Lab at Biological Research Center and Biomaterial Lab at School of Pharmacy. During past three years, my group has developed different methods and techniquesfor producing micro- and nano-particles and fibers for drug/gene delivery and tissue engineering which made my Lab a regional reference in micro- and nano-biotechnology in thewest of Iran. Even, theeffort of my Lab members in developing simple methods for producing microfluidic chips made our group one of the pioneers in thebiological application of microfluidics in Iran. Already, I am conducting several projects on theapplication of microfluidics for industrial production of microspheres and bioartificial pancreas.

I have been actively involved in teaching and supervising students since I have started my work at KUMS. I provide formal lectures on novel drug delivery, powders, polymers, tissue engineering and biomaterials for pharmacy students, masterstudents of bioelectric and Ph.D. students of nano-biotechnology at KUMS, Yazd University of Medical Sciences and Razi University.Until now, 20 Pharm D and MS students were graduated under my direct supervision, and 2 Pharm D, MS and 7Ph.D. students are already working on my Labs. I was also theadvisor of several theses from Pharmacy, Medicine and Dentistry Schools of KUMS.