Reza Khodarahmi

Reza Khodarahmi
Full Prof.
PhD of Biochemistry
1School of Pharmaceutical Sciences (and Medical Biology Research Center), Kermanshah University of
Medical Sciences, Kermanshah, IRAN
2Biochemistry Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah,
IRAN
e-mail: rkhodarahmi@mbrc.ac.ir
Personal Records
Name: Reza Khodarahmi
Date of Birth: August 4, 1974
Nationality: Iranian
Gender: Male
Place of Birth: Nahavand, Iran
Marital Status: Married, 2 Children
Appointment: PhD in Biochemistry
Address: Faculty of Pharmacy, Kermanshah
University of Medical Sciences, Kermanshah, Iran
Telephone: +98‐9122388184
Fax: +98‐831‐4276493
e-Mail: rkhodarahmi@kums.ac.ir and
rkhodarahmi@mbrc.ac.ir
Languages:
I know Farsi (native) and English (semi‐fluently).
Present Position: Associate Prof. of Biochemistry
Educational Records
B.Sc:
From: University of Razi, Kermanshah, Iran (1997)
Major: Biology
M.Sc:
From: Faculty of Sciences, University of Tarbiat‐Modarres, Tehran, Iran (2000)
Major: Pure Biochemistry
Thesis: Development of a new affinity gel for purification of glycoproteins.
Ph.D:
From: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran (2001‐2006)
Major: Applied Biotechnology
Thesis: The effects of new chemical chaperones on the extent of aggregation of recombinant proteins
during the refolding processes.
Courses Taught
A. Undergraduate
1. General Biochemistry
2. Metabolism
2001‐2008 Biochemistry (Metabolism) for B.S. students at Azad and Razi University
2005‐2008 Biochemistry (Metabolism) at Faculty of Pharmacy and Veterinary
Medicine
B. Graduate (M. Sc.)
1. Enzymology and Enzyme Kinetics
2. Translation and control of gene expression
3. Bioinformatics
Activity in Scientific Journals
Chairman: Journal of Reports in Pharmaceutical Sciences
Academic Editor: PLOS ONE
Reviewer: PLOS ONE, International journal of Biological Macromolecules, Archives of
Biochemistry and Biophysics, Medicinal Chemistry Research, Cytotechnology,
Pharmaceutical Biology, Journal of Iranian Chemical Society, Spectrochimica Acta A
Molecular and Biomolecular Spectroscopy, Cell biochemistry and Biophysics,
Biotechnology Progress, ERMS, JKUMS, . .
Researches and Interests
- 1999‐2000 Study on hemoglobin as a ligand for affinity chromatography
under supervision of Dr. Hamid Rahi, Kermanshah University of medical
Sciences, Kermanshah, Iran
- 2000‐2001 National Project of "Expression and Purification of recombinant
human interferon a2b" in Pasteur Institute, under supervision of Dr. Mehraeen,
Tehran, Iran.
- 2003‐2005 Study on refolding strategies (Downstream of Biotechnology)
under supervision of Dr. Yazdanparast, University of Tehran, Tehran, Iran
1- Protein aggregation, Amyloidosis and its inhibition
2- Protein‐Ligand (Drug) interaction
3- Enzyme Kinetics and Inhibition
Honors and Awards
1. Top B.Sc student of Biology Department, Razi University, 1997.
2. Top M.Sc student of Biochemistry Department, Faculty of Sciences, Tarbiat
Modarres University, 2000.
3. Distinguished as young scientist in 8th Iranian congress of Biochemistry and First
international congress of Biochemistry and molecular Biology, September 11‐15,
2005.
4. Distinguished researcher in University of Tehran, 2006.
5. Distinguished teacher in Kermanshah University of Medical Sciences.
6. Distinguished researcher in Kermanshah University of Medical Sciences (2009‐
2014).
Membership of Scientific Societies
- Member of Iranian Society of Biophysical Chemistry (ISOBC).
- Member of Iranian Society of Biochemistry.
- Member of Iranian Peptide Society.
- Member of Iranian Biology Society.
Publications
(Books in Persian)
1- Biochemistry and Biophysics of Metabolism, Noor-e-Danesh Publication,
Tehran, Iran, 2003 (Second edition, 2008) Reza Khodarahmi and Nooshin
Bahrami Ghane (www.noordanesh‐pub.com)
2- From wheat grains to bread loaves, “Biochemistry of wheat” Chapter, First
international congress of wheat, Tehran, Iran, 2002, Boards of Authors
(Published Full Journal Papers) – H-index: 12 (Sep 2016)
http://scholar.google.com/citations?user=X4LPEEIAAAAJ&hl=en
https://www.researchgate.net/profile/Reza_Khodarahmi/reputation
86. Captopril/enalapril inhibit promiscuous esterase activity of carbonic
anhydrase at micromolar concentrations: An in vitro study, S Esmaeili, MR Ashrafi‐
Kooshk, H Adibi, R Khodarahmi, Chemico‐Biological Interactions, DOI:
10.1016/j.cbi.2017.01.014.
85. Diethylalkylsulfonamido (4‐methoxyphenyl) methyl)
phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors:
synthesis accompanied by experimental and molecular modeling assessments
N Alimoradi, MR Ashrafi‐Kooshk, M Shahlaei, S Maghsoudi, Hadi Adibi, Ross P
McGeary, Reza Khodarahmi, Journal of Enzyme Inhibition and Medicinal
Chemistry, http://dx.doi.org/10.1080/14756366.2016.1230109
84. A Spectrophotometric Method for the Determination of Aldehyde Oxidase
Activity Using 3‐Methyl‐2‐ Benzothiazolinone Hydrazine: A Preliminary Study ,
Maryam Siah · Mohammad Hosein Farzaei, Mohammad Reza Ashrafi, Hadi Adibi,
Reza Khodarahmi, 2017, 6(1), 23‐33.
83. Appraisal of role of the polyanionic inducer length on amyloid formation by
412‐residue 1N4R Tau protein: A comparative study, A Jangholi, MR Ashrafi‐
Kooshk, SS Arab, G Riazi, F Mokhtari, ... R. Khodarahmi, Archives of Biochemistry
and Biophysics 609, 1‐19, 2016. (Q1)
82. Is there correlation between Aβ‐heme peroxidase activity and the peptide
aggregation state? A literature review combined with hypothesis, R Khodarahmi,
MR Ashrafi‐Kooshk, International Journal of Biological Macromolecules, 2016.
81. Degradation products of the artificial azo dye, Allura red, inhibit esterase
activity of carbonic anhydrase II: A basic in vitro study on the food safety of the
colorant in terms of enzyme inhibition, S Esmaeili, MR Ashrafi‐Kooshk, K
Khaledian, H Adibi, S Rouhani, ... R. Khodarahmi, Food Chemistry 213, 494‐504,
2016. (Q1)
80. Heme‐coordinated histidine residues form non‐specific functional “ferritinheme”
peroxidase system: Possible and partial mechanistic relevance to oxidative
stress‐mediated pathology in neurodegenerative diseases, S Esmaeili, MRA
Kooshk, SM Asghari, R Khodarahmi, International journal of biological
macromolecules 91, 368‐380, 2016.
79. Peptides NAP and SAL attenuate human tau granular‐shaped oligomers in
vitro and in SH‐SY5Y cells, F Mokhtari, G Riazi, S Balalaie, R Khodarahmi, S
Karima, A Hemati, ..., Neuropeptides 59, 21‐31, 2016.
78. Plant Cell Cancer: May Natural Phenolic Compounds Prevent Onset and
Development of Plant Cell Malignancy? A Literature Review, H Rasouli, MH Farzaei,
K Mansouri, S Mohammadzadeh, R Khodarahmi, Molecules 21 (9), 1104, 2016.
77. Critical Effects on Binding of Epidermal Growth Factor Produced by Amino
Acid Substitutions, M Mehrabi, R Khodarahmi, M Shahlaei, Journal of
Biomolecular Structure and Dynamics, 1‐60, 2016
76. Synthesis, Characterization, Molecular Modeling, and DNA Interaction Studies
of Copper Complex Containing Food Additive Carmoisine Dye, N Shahabadi, A
Akbari, M Jamshidbeigi, R Khodarahmi, Nucleosides, Nucleotides and Nucleic
Acids, 1‐19, 2016.
75. Functionalization of γ‐Fe 2 O 3@ SiO 2 nanoparticles using the antiviral drug
zidovudine: synthesis, characterization, in vitro cytotoxicity and DNA interaction
studies, N Shahabadi, M Falsafi, F Feizi, R Khodarahmi, RSC Advances 6 (77),
73605‐73616, 2016.
74. Inhibition of guinea pig aldehyde oxidase activity by different flavonoid
compounds: An in vitro study, M Siah, MH Farzaei, MR Ashrafi‐Kooshk, H Adibi, SS
Arab, MR Rashidi, R Khodarahmi. Bioorganic chemistry 64, 74‐84, 2016.
73. Exploring binding properties of sertraline with human serum albumin:
Combination of spectroscopic and molecular modeling studies, M Shahlaei, B
Rahimi, A Nowroozi, MR Ashrafi‐Kooshk, K Sadrjavadi, R Khodarahmi.
Chemico‐biological interactions 242, 235‐246, 2015.
72. Possible peroxidase active site environment in amyloidogenic proteins: Native
monomer or misfolded‐oligomer; which one is susceptible to the enzymatic
activity, with contribution of heme?
R Khodarahmi, MR Ashrafi‐Kooshk, S Khodarahmi, SA Ghadami, ...
International Journal of Biological Macromolecules 80, 293‐301
71. Allura Red, the Artificial Azo Dye, Inhibits Esterase Activity of Carbonic
Anhydrase II: A Preliminary Study on the Food Safety in Term of Enzyme
Inhibition, R Khodarahmi, MR Ashrafi‐Kooshk, K Khaledian, Journal of Reports in
Pharmaceutical Sciences (J. Rep. Pharm. Sci.) 4 (1), 43‐52
70. Spectroscopic and molecular modeling studies on binding of dorzolamide to
bovine and human carbonic anhydrase II, N Bijari, S Ghobadi, H Mahdiuni, R
Khodarahmi, SA Ghadami, International journal of biological macromolecules 80,
189‐199
69. Comparative studies on drug binding to the purified and pharmaceutical‐grade
human serum albumins: Bridging between basic research and clinical applications
of albumin, Mohammad Reza Ashrafi‐Kooshk, Farangis Ebrahimi, Samira Ranjbar,
Sirous Ghobadi, Nastaran Moradi, Reza Khodarahmi, Biologicals
68. Engineering of a disulfide loop instead of a Zn binding loop restores the antiproliferative,
anti‐angiogenic and anti‐tumor activities of the N‐terminal fragment
of endostatin: Mechanistic and therapeutic insights
Reyhane Chamani, S Mohsen Asghari, Ali Mohammad Alizadeh, Sedigheh
Eskandari, Kamran Mansouri, Reza Khodarahmi, Majid Taghdir, Zahra Heidari,
Ali Gorji, Alireza Aliakbar, Bijan Ranjbar, Khosro Khajeh, Vascular pharmacology
67. Enhancement of thermal reversibility and stability of human carbonic
anhydrase II by mesoporous nanoparticles
A Khatibi, L Ma’mani, R Khodarahmi, A Shafiee, P Maghami, F Ahmad, ...
International journal of biological macromolecules 75, 67‐72
66. Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and
Surface Hydrophobicity
B. Mannini, E. Mulvihill ,C. Sgromo, R. Cascella, R. Khodarahmi, M. Ramazzotti, C.
M. Dobson, C. Cecchi, F. Chiti
ACS Chem. Biol., DOI: 10.1021/cb500505m
65. Spectroscopic Study of drug‐binding characteristics of unmodified and pNPAbased
acetylated human serum albumin: Does esterase activity affect
microenvironment of drug binding sites on the protein?
Nastaran Moradi, Mohammad Reza Ashrafi‐Kooshk, Sirous Ghobadi, Mohsen
Shahlaei, Reza Khodarahmi, Doi:10.1016/j.jlumin.2014.11.019, Journal of
Luminescence.
64. Appearance and Disappearance of Chronic Myeloid Leukemia (CML) in Patient
with Chronic Lymphocytic Leukemia (CLL)
Mehrdad Payandeh, Edris Sadeghi, Reza Khodarahmi, Masoud Sadeghi
International Journal of Hematology‐ Oncology and Stem Cell Research, 1 October
2014. Volume 8, Number 4, 49‐53.
63. The efficacy of erlotinib as molecularly targeted maintenance therapy in
advanced non‐small‐cell lung cancer (NSCLC): Case reports in western Iran
Mehrdad Payandeh, Reza Khodarahmi, Masoud Sadeghi, Edris Sadeghi
Journal of Solid Tumors, 2014, Vol. 4, No. 3, 38‐44
62. Direct Evidence for Nonspecific Peroxidase Activity of ''Ferritin‐Heme"
complex: Possible Role in the Development of Neurodegenerative Diseases.
Morteza Jaafari, Mohammad Reza Ashrafi Kooshk, Seyyed Mohsen Asghari, Ali
Akbar Moosavi‐Movahedi, Sirous Ghobadi, Reza Khodarahmi,
J. Iran. Chem. Society, DOI: 10.1007/s13738-014-0538-z.
61. Probing of possible olanzapine binding site on Human Serum Albumin:
Combination of spectroscopic methods and molecular dynamics simulation
Reza Khodarahmi, Mohsen Shahlaei, Behnoosh Rahimi, Mohammad Reza Ashrafi‐
Kooshk, Komail Sadrjavadi, Journal of Luminescence 158 (2015) 91–98
60. Purification and biochemical characterisation of glucoamylase from a newly
isolated Aspergillus niger: Relation to starch processing
A. Bagheri, R. Khodarahmi, A. Mostafaie
Food chemistry, 2014, 161, 270‐278
59. Application of radial basis function neural network and DFTquantum
mechanical calculations for the prediction of the activity of 2‐biarylethylimidazole
derivatives as bombesin receptor subtype‐3 (BRS‐3) agonists
M. Shahlaei, A. Nowroozi, R. Khodarahmi
Medicinal Chemistry Research, 2014, 23, 8, 3681‐3693
58. Evidence of human hemoglobin interaction and chorionic gonadotropin
hormone: Prospects for the use of hemoglobin as ligand in affinity
chromatography for the purification of the hormone
R. Khodarahmi, S. Maghsoodi, H. Rahi, K. Hamzehee, S. Zamaheni, E. Davarpanah
Journal of Paramedical Sciences, 2014, 5 (3)
57. The Role of Anionic Peptide Fragments in 1N4R Human Tau Protein
Aggregation
M. Ali Nasiri Khalili, G. Riazi, S. Ahmadian, R. Khodarahmi, S. Khodadadi, A.
Afrasiabi, O. Karima, F. Mokhtari, E. Hoveizi
Protein and peptide letters, 2014, 21 (6), 511‐516
56. Does Long‐Term Administration of a Beta‐Blocker (Timolol) Induce Fibril‐
Based Cataract Formation In‐vivo?
M.R. Nikbakht, M.R. Ashrafi‐Kooshk, M. Ghasemi, R. Khodarahmi
Iranian Journal of Pharmaceutical Research, 2014, 13 (2), 599‐611
55. A Combined DFT and QSAR Calculations to Study Substituted Biphenyl
imidazoles as Bombesin Receptor Subtype‐3 Agonists
M. Shahlaei, A. Nowroozi, R. Khodarahmi
Letters in Drug Design & Discovery, 2014, 11 (5), 665‐676
54. Comparative spectroscopic studies on Curcumin Stabilization by Association to
Bovine Serum Albumin and Casein: A perspective on drug‐delivery application
M.M. Nadi, M.R. Ashrafi Kooshk, K. Mansouri, S.A. Ghadami, M. Amani, S. Ghobadi,
R. Khodarahmi
International Journal of Food Properties, 2014
53. In vitro Anti‐angiogenic Activity of Persian Shallot (Allium Hirtifolium) Extract
Is Mediated Through Inhibition of Endothelial Cell Proliferation/Migration and
Down‐regulation of VEGF and MMP Expression
D. Arshadi, K. Mansouri, R. Khodarahmi, P. Seyfi, Y. Shakiba, A. Mostafaie
Journal of Reports in Pharmaceutical Sciences (J. Rep. Pharm. Sci.), 2014, 3 (1), 65‐
78
52. Antioxidant status in patients with psoriasis
H. Nemati, R. Khodarahmi, M. Sadeghi, A. Ebrahimi, M. Rezaei, A. Vaisi‐Raygani
Cell Biochem Funct 2014, 32: 268‐273
51. Proteins expression clustering of Alzheimer disease in rat hippocampus
proteome
H. Zali, M.R. Tavirani, F.A. Jalilian, R. Khodarahmi
Journal of Paramedical Sciences,2014, 4 (3)
50. Protective effects of accompanying proteins on light‐and water‐mediated
degradation of Curcumin
F. Mirzaee, M.R.A. Kooshk, M. Rezaei‐Tavirani, R. Khodarahmi
Journal of Paramedical Sciences, 2014, 5 (1)
49. Anovel, efficient, fast and inexpensive DNA extraction protocol from whole
blood applicable for studying drug‐DNA interaction
M. T. Moradi, K. Yari, R. Khodarahmi
Journal of reports in pharmaceutical science, 2014, 3(1), 79‐83
48. Mushroom tyrosinase inhibition by benzaldehyde derivatives
S. Maghsoudi, H. Adibi, M. Hamzeh, M. R. Ashrafi, M. Rezaei‐Tavirani, R.
Khodarahmi
Journal of reports in pharmaceutical science, 2013, 2(2), 67‐75
47. Spectroscopic study of interaction between osthole and human serum albumin:
identification of possible binding site of the compound
N. Bijari, Y. Shokoohinia, M.R. Ashrafi‐Kooshk, S. Ranjbar, S. Parvaneh, M. Moieni‐
Arya, R. Khodarahmi
Journal of Luminescence, 2013, 143, 328‐336
46. Studies of the Interaction between Isoimperatorin and Human Serum Albumin
by Multispectroscopic Method: Identification of Possible Binding Site of the
Compound Using Esterase Activity of the Protein
S. Ranjbar, Y. Shokoohinia, S. Ghobadi, N. Bijari, S. Gholamzadeh, N. Moradi, M.R.
Ashrafi‐Kooshk, A. Aghaei, R. Khodarahmi
The Scientific World Journal, 2013
45. Molecular Chaperones or Amyloid‐binding compounds? Perspective on Their
Application as Possible Therapeutic Agents in Reduction of Cytotoxicity of Amyloid
Oligomers
R. Khodarahmi
Journal of Reports in Pharmaceutical Sciences, 2013, 2 (2), 205‐206
44. Carbonic Anhydrases: Battlefield for Enzyme Inhibitor and Activator Drugs?
R. Khodarahmi
Journal of Paramedical Sciences, 2013, 4 (4)
43. Methylentetrahydrofolatereductase (rs1801133) polymorphism and psoriasis:
contribution to oxidative stress, lipid peroxidation and correlation with vascular
adhesion protein 1, preliminary report
M. Asefi, A. Vaisi‐Raygani, R. Khodarahmi, H. Nemati, Z. Rahimi, H. Vaisi‐Raygani,
H. Tavilani, T. Pourmotabbed
Journal of the European Academy of Dermatology and Venereology, 2013
42. In Vitro Anti‐Cancer Activity of Native Curcumin and “Protein‐Curcumin”
Systems: A Perspective on Drug‐Delivery Application
M.R. Ashrafi Kooshk, K. Mansouri, M.M. Nadi, S. Khodarahmi, R. Khodarahmi
Journal of Reports in Pharmaceutical Sciences, 2013, 2 (1), 66‐74
41. Appraisal of sildenafil binding on the structure and promiscuous esterase
activity of native and histidine‐modified forms of carbonic anhydrase II
H. Mahdiuni, N. Bijari, M. Varzandian, S.A. Ghadami, M. Khazaei, M.R. Nikbakht, R.
Khodarahmi
Biophysical chemistry, 2013, 175, 1‐16
40. Synthesis and investigation of antioxidant activities of 2‐benzylidene‐3‐
coumaranones
H. Adibi, A. Foroumadi, R. Khodarahmi, K. Najafi, M. Rezaei‐Tavirani
Journal of Paramedical Sciences, 2013, 4 (2)
38. Modified β‐casein restores thermal reversibility of human carbonic anhydrase
II: The salt bridge mechanism
A. Fallah‐Bagheri, A.A. Moosavi‐Movahedi, M. Taghizadeh, R. Khodarahmi, L.
Mamani, N. Bijari, M. Bohlooli, A. Shafiee, N. Sheibani, A.A. Saboury
Biotechnology and applied biochemistry, 2013, 60 (3), 298‐304
37. Synthesis of 4‐Aryl‐4H‐Chromene Derivatives with Boric Acid: Evaluation of
Their in vitro Anti‐Angiogenesis Effects and Possible Mechanism of Action
H. Adibi, R. Khodarahmi, K. Mansouri, M. Khaleghi, S. Maghsoudi
35. Molecular approaches in obesity studies
M. Zamanian‐Azodi, R. Vafaee, T. Azodi, R. Omidi, S. Gilanchi, F. Azizi‐Jalilian, R.
Khodarahmi
Gastroenterology and Hepatology from bed to bench, 2013, 6 (Suppl 1), S23
36. Synthesis and in vitro characterization of some benzothiazole‐and
benzofuranone‐ derivatives for quantification of fibrillar aggregates and inhibition
of amyloid‐mediated peroxidase activity
S.A. Ghadami, Z. Hossein‐pour, R. Khodarahmi, S. Ghobadi, H. Adibi,
Medicinal Chemistry Research,2013, Vol 22, page 115‐126.
35. Effect of essential oil of rosa damascena on human colon cancer cell line
SW742
M. Rezaie‐Tavirani, S. Fayazfar, S. Heydari‐Keshel, M.B. Rezaee, M. Zamanian‐
Azodi, M. Rezaei‐Tavirani, R. Khodarahmi
Research Institute for Gastroenterology and Liver Diseases, 2013, vol 6, pages 25
34. Comparative evaluation of amphotericin B binding to the native and modified
forms of rice lipid‐transfer protein: a possible perspective on improving the drugbinding
affinity and specificity
S. Maghsoudi, M.R. Ashrafi‐Kooshk, M. Shahlaei, S.A. Ghadami, S. Ghobadi, A.
Mostafaie, R. Khodarahmi
Journal of the Iranian Chemical Society, 2013, DOI 10.1007/s13738‐013‐0231‐7.
33. Antibacterial effects of Scrophularia striata seed aqueous extract on
staphylococcus aureus
M. Zamanian‐Azodi, A. Ardeshiry Lajimi, N. Ahmadi, M.B. Rezaee, F. Jalalian, R.
Khodarahmi
Journal of Paramedical Sciences, 2013, Vol.4, No.1, page 58 – 62.
32. An in vitro model for spontaneous angiogenesis using rat mesenteric
endothelial cells: Possible therapeutic perspective for obesity and related
disorders
K. Mansouri, R. Khodarahmi, and S.A. Ghadami
pharmaceutical biology, 2013, DOI: 10.3109/13880209.2013.773452.
31. Serum lipid profile in psoriatic patients in Kermanshah: a survey on vascular
adhesion protein‐1
H. Nemati, R. Khodarahmi, M. Sadeghi, A. Rahmani, M. Rezaei
ZJRMS, 2013, 15(2), 8‐10
30. Seventeen years of science production among researchers of Kermanshah
University of Medical sciences (1995‐2011) based on Web of Science (WOS)
F. Foroughi, K. Hamzehee, A. Foroughinia, F. Najafi, R. Khodarahmi, A. Saleki
Journal of Kermanshah University of Medical Sciences, 2012, 16 (7), 549‐56
29. Structural and functional impacts of albumin oxidation by hypochlorite:
possible changes in drug binding characteristics upon myeloperoxidase‐ mediated
oxidation in vivo
M.R. Ashrafi Kooshk, R. Khodarahmi, S.A. Karimi, M.R. Nikbakht,
Journal of Reports in Pharmaceutical Sciences, 2012, vol 1,pages 80‐92.
28. Spectroscopic characterization of furosemide binding to human carbonic
anhydrase II
S. Ranjbar, S. Ghobadi, R. Khodarahmi, H. Nemati
International Journal of Biological Macromolecules, Volume 50, Issue 4, 2012,
Pages 910‐917.
27. Serum lipid profile in psoriatic patients: correlation between vascular adhesion
protein 1 and lipoprotein
H. Nemati, R. Khodarahmi, A. Rahmani , A. Ebrahimi , M. Amani and K. Eftekhari
Cell biochemistry and function, 2012, DOI: 10.1002/cbf.2857.
26. Non‐specific peroxidase activity and catalase‐inhibitory behavior of fibrillar
aggregates after interaction with heme: relevance to the etiology of amyloidrelated
neurodegenerative disorders using the experimental‐based evidences
R. Khodarahmi, Z. Hossein‐pour, S. Ghobadi, K. Mansouri, A. Mostafaie, K. Yari, S.A.
Ghadami
Journal of the Iranian Chemical Society, 2012, Vol 9(6),pages 939‐950.
25. Effects of silica nanoparticle supported ionic liquid as additive on thermal
reversibility of human carbonic anhydrase II
A. Fallah‐Bagheri, A.A. Saboury, L. Ma’mani, M. Taghizadeh, R. Khodarahmi, S.
Ranjbar, M. Bohlooli, A. Shafiee, A. Foroumadi, N. Sheibani, A.A. Moosavi‐Movahedi
International Journal of Biological Macromolecules, 2012 Vol 51, Pages 933‐938.
24. Comparative studies on drug binding characteristics and protein surface
hydrophobicity of native and modified forms of bovine serum albumin: possible
relevance to change in protein structure upon glycation
R. Khodarahmia, S.A. Karimi, M.R. Ashrafi Kooshk, S.A. Ghadamia, S. Ghobadic, M.
Amani
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012, vol
89, page 177–186.
23. Challenge in cancer therapy with vap‐1 inhibition strategy: possible interferece
of this type of intervention within protection from autoimmunity: hypothesis
M.E. Zare, R. Khodarahmi, S.A. Ghadami, A. Nasir Kansestani
Journal of Reports in Pharmaceutical Sciences, 2012, vol 1, pages 104‐108.
22. Amyloidogenic proteins in their fibrillar states may be detrimental via different
mechanisms: perspective of potential curative/preventive strategies against
neurodegenerative disorders
R. Khodarahmi, Z. Hossein‐pour, K. Mansouri, S.A. Ghadami
Journal of Reports in Pharmaceutical Sciences, 2012, Vol 1, page 23 – 33.
21. Differential scanning calorimetry study on thermal denaturation of human
carbonic anhydrase II
M. Amani, R. Khodarahmi, S. Ghobadi, M. Mehrabi, B.I. Kurganov, A.A. Moosavi‐
Movahedi
Journal of Chemical & Engineering Data, 2011, 56 (4), 1158‐1162
20. Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms
M. Payandeh, F.S. Zadeh, M.E. Zare, K. Mansouri, R. Khodarahmi, S. Alimoradi, H.
Yousefi, F. Darabi
International Journal of Hematology‐Oncology and Stem Cell Research, 2011, 5 (3),
16‐20
19. Artemin as an efficient molecular chaperone: in vitro, in vivo and theoretical
studies
S. Shahangian, B. Rasti, R. H. sajedi, R. Khodarahmi, M. Taghdir, B. Ranjbar,
protein journal, 2011, vol 30(8), page 549‐557.
18. Anti‐angiogenic/proliferative behavior of a “4‐aryl‐4H‐chromene” on blood
vessel’s endothelial cells: A possible evidence on dual “anti‐tumor” activity
K. Mansouri, R. Khodarahmi, A. Foroumadi, A. Mostafaie and H. Mohammadi
Motlagh,
Medicinal Chemistry Research, 2011, 20(7), page 920 – 929.
17. Amyloid fibril formation by native and modified bovine β‐lactoglobulins
proceeds through unfolded form of proteins: A comparative study
S.A. Ghadami, R. Khodarahmi, S. Ghobadi, M. Ghasemi, S. Pirmoradi .
Biophysical Chemistry, 2011, Vol 159(2–3), Pages 311‐320.
16. Heme, as a chaperone, binds to amyloid fibrils and forms peroxidase in vitro:
Possible evidence on critical role of non‐specific peroxidase activity in
neurodegenerative disease onset/progression using the α‐crystallin‐based
experimental system
R. Khodarahmi, F. Naderi, A. Mostafaie, K. Mansouri,
Archives of Biochemistry and Biophysics, 2010, Vol 494,pages 205‐215.
15. Study of Cosolvent‐Induced α‐Chymotrypsin Fibrillogenesis: Does Protein
Surface Hydrophobicity Trigger Early Stages of Aggregation Reaction?
R. Khodarahmi, H. Soori and M. Amani
The Protein Journal, 2009, Vol 28, Pages 349‐361.
14. Spectroscopic study on the interaction of celecoxib with human carbonic
anhydrase II: Thermodynamic characterization of the binding process
M. Mehrabi, S. Ghobadi, R. Khodarahmi,
Journal of Photochemistry and Photobiology B: Biology, 2009, Vol 9, pages 161‐
168.
13. Chaperone‐like activity of Heme group against amyloid‐like fibril formation by
hen egg ovalbumin: Possible mechanism of action
R. Khodarahmi, H. Soori and S. A. Karimi
International Journal of Biological Macromolecules, 2009, Vol 44, Pages 98‐106.
12. Anti‐Angiogenic Effect of Aqueous Extract of Shallot (Allium ascalonicum)
Bulbs in Rat Aorta Ring Model
H.R. Mohammadi Motlagh, K. Mansouri, Y. Shakiba, M. Keshavarz, R. Khodarahmi,
A. Siami, A. Mostafaie. Yakhteh
Medical Journal, 2009, Vol 11 (2)Pages: 190‐195.
11. Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities
of Nacylsulfonamides using silica sulfuric acid as an efficient catalyst under both
solvent‐free and heterogeneous conditions
A.R. Massah, H. Adibi, R. Khodarahmi, R. Abiri, M.B. Majnooni, S. Shahidi, B. Asadi,
M. Mehrabi and M.A. Zolfigol
Bioorganic & Medicinal Chemistry 16 (2008) 5465–5472.
10. Appraisal of casein’s inhibitory effects on aggregation accompanying carbonic
anhydrase refolding and heat induced ovalbumin fibrillogenesis
R. Khodarahmi, M. Beyrami , H. Soori ,
Archives of Biochemistry and Biophysics , 2008, 477 ,pages 67–76.
9. Evaluation of TRAPand FRAP methods for assessing total antioxidant capacity of
rat serum
N.H. Tayefi, R. Khodarahmi
Scientific Information Database, 2007, 9(3(33)), 41‐47
8. Protein refolding assisted by molecular tube based α‐cyclodextrin as an artificial
chaperone
R. Yazdanparast, M.A. Esmaeili and R. Khodarahmi
Biochemistry (Moscow), 2006, Vol 7(12), Pages 1298‐1306.
7. The Combined effects of two anti‐aggregatory agents, α‐cyclodextrin and Ca2+,
on the refolding process of denatured α‐amylase
R. Yazdanparast and R. Khodarahmi
Biotechnol. Appl. Biochem., 2005, 41, 157‐162.
6. Suppression effect of guanidine hydrochloride on α‐cyclodextrin‐assisted
refolding of denatured α‐amylase
R. Khodarahmi and R. Yazdanparast
Process Biochem., 2005, 40, 2973‐2979.
5. Fluorimetric study of the artificial chaperone‐assisted renaturation of carbonic
anhydrase: a kinetic analysis
R. Khodarahmi and R. Yazdanparast
Int. J. Biol. Macromol., 2005, 36, 191‐197.
4. Evaluation of artificial chaperoning behavior of an insoluble cyclodextrin‐rich
copolymer: Solid‐phase assisted refolding of carbonic anhydrase
R. Yazdanparast and R. Khodarahmi
Int. J. Biol. Macromol., 2005.
3. Comparative studies of the artificial chaperone‐assisted refolding of thermally
denatured bovine carbonic anhydrase using different capturing ionic detergents
and β‐ cyclodextrin
R. Yazdanparast, R. Khodarahmi and H. Soori
Arch. Biochem. Biophys., 2005, 437, 178‐185.
2. Artificial chaperone‐assisted refolding of chemically denatured α‐amylase
R. Yazdanparast, F. Khodagholi and R. Khodarahmi,
Int. J. Biol. Macromol., 2005, 35, 257‐263.
1. Refolding of chemically denatured α‐amylase in dilution additive mode
R. Khodarahmi and R. Yazdanparast
Biochim. Biophys. Acta, 2004, vol 1674, 175‐181.
مقالات فارسی:
بر میزان قند و چربی هاي خون در موش هاي (Morus alba L.) 6. بررسی اثر عصاره ي آبی برگ توت سفید
صحرائی نر، رحمت اله پرندین، رضا خدارحمی، شفیع امینی مقدم، 1389 ، فصلنامه داروهاي گیاهی، پیش شماره
. 3، صفحه 35 تا 42
5. بررسی اثر آنتی بیوتیکی عصاره آبی گیاه اسکروفولاریا استریاتا بر اشرشیاکلی در مقایسه با تتراسایکلین، مونا
زمانیان عضدي، عبدالرضا اردشیري لاجیمی، مصطفی رضایی طاویرانی، مجید رضایی طاویرانی، رضا خدارحمی، مجله
.133 - علمی دانشگاه علوم پزشکی ایلام، 1391 ، دوره 20 ، شماره 4 صفحه 127
4. تخلیص فریتین از کبد گوسفند و گزارش فعالیت پراکسیدازي مجموعه هیم- فریتین، سمیرا رنجبر، مرتضی
جعفري، رضا خدارحمی، زهرا زارعی، محمد رضا اشرفی، سیدشهرام آقائی، مجله علمی دانشگاه علوم پزشکی ایلام،
.126 - 1391 ، دوره 20 ، شماره 4 صفحه 117
،1390 - سال 1374 (wos) . 3. هفده سال تولید علم دانشگاه علوم پزشکی کرمانشاه بر اساس پایگاه استنادي علم
فیض اله فروغی، کورش حمزه اي، آزاده فروغی نیا، رضا خدارحمی، فرید نجفی، علیرضا سالکی، ماهنامه علمی
.561- پزوهشی علوم پزشکی کرمانشاه، 1391 ، سال 12 ، شماره 7، صفحه 549
جهت تعیین پتانسیل آنتی اکسیدانی تام سرم موش صحراي، حسین طایفی نصر FRAP و TRAP 2. ارزیابی دو روش
.47 – آبادي، رضا خدارحمی، 1386 ، فصلنامه علمی پژوهشی یاخته، دوره نهم، شماره 3، صفحه 41
1. بررسی اثر ضد رگ زایی عصاره ابی پیازچه مو سیر در مدل حلقه ائورت موش صحرائی، حمید رضا محمدي مطلق،
کامران منصوري، یدالله شکیبا، مریم کشاورز، رضا خدارحمی، عباس صیامی، علی مصطفایی، 1387 ،فصل نامه
.195 - پزشکی یاخته، سال یازدهم، شماره 2، صفحه 191
Congresses and symposiums
37. Effect of Sudlow site I drugs on human serum albumin esterase‐like activity,
N. Moradi, R. Khodarahmi, M.R. Ashrafi‐Kooshk, 1st Tabriz International
Life Science Conference and 12th Iran Biophysical, 2013.
36. The effects of glibenclamide on the kinetic parameters of esterase activity
of human carbonic anhydrase ΙΙ, S. Ghobadi, M. Pazhohi, R. Khodarahmi,
1st Tabriz International Life Science Conference and 12th Iran Biophysical ,
2013.
35. Improving the stability and antioxidant activity of curcumin upon
interaction with native and acetylated forms of albumin, casein and β‐
Lactoglobulin: A comparative study with perspective of functional food
application, F. Mirzaee, R. Khodarahmi, M.R. Ashrafi‐Kooshk, 1st Tabriz
International Life Science Conference and 12th Iran Biophysical, 2013.
34. Serum Lipid Profile in Psoriatic Patients in Kermanshah: A Survey on
Vascular Adhesion Protein‐1, H. Nemati, R. Khodarahmi, M. Sadeghi, A.
Rahmani, M. Rezaei, Zahedan Journal of Research in Medical Sciences, 2013,
15 (2), 8‐10.
33. Traumatic spinal cord lesions: Impact of comprehensive nursing care, F.
Roshanpour, R. Pourmirza, R. Khodarahmi, A. Saleki, Journal of Injury and
Violence Research, 2012, 4 (3 Suppl 1)
32. A Possible Role of Peroxidase Activity of ‘‘heme‐ferritin” Complex in
Development of Neurodegenerative diseases, M. Jafari, R. Khodarahmi, S.
Ranjbar, M. R. Ashrafi, S. M. Asghari, , The First International & 11th Iran
Biophysical Chemistry Conference, 13‐15 June 2012, Ardabil University of
Medical Sciences, Ardabil, Iran.
31. Effects of dorzolamide on thermal aggregation and flexibility of bovine
carbonic anhydrase II, N. Bijari, S. Ghobadi, R. Khodarahmi, The 17th
National & 5th International Iranian Biology Conference, 4‐6 September
2012, Shahid Bahonar University of Kerman, Kerman, Iran.
30. Comparative spectroscopic characterization of the interaction of
dorzolamide with bovine and human carbonic anhydrase II, N. Bijari, S.
Ghobadi, R. Khodarahmi, S. A. Ghadami, The 17th National & 5th
International Iranian Biology Conference, 4‐6 September 2012, Shahid
Bahonar University of Kerman, Kerman, Iran.
29. Effect of topiramate on the thermodynamic and kinetic stability of human
carbonic anhydrase, M.R. Ashrafi Kooshk, S. Ghobadi, R. Khodarahmi, The
17th National & 5th International Iranian Biology Conference, 4‐6 September
2012, Shahid Bahonar University of Kerman, Kerman, Iran.
28. Investigation on the Effects of Glibenclamide on the Structure and Function
of Human Carbonic Anhydrase ІІ, S. Ghobadi, R. Khodarahmi, M. Pazhohi,
S. A. Ghadami, N. Bijari, The First International & 11th Iran Biophysical
Chemistry Conference, 13‐15 June 2012, Ardabil University of Medical
Sciences, Ardabil, Iran.
27. Detection of Fibrillar Aggregates and Inhibition of Amyloid‐Mediated
Peroxidase Activity Using the Novel Benzothiazoleand Benzofuranone‐
Derivatives Fluorescence Compounds, S.A. Ghadami, R.Khodarahmi, H.
Adibi, S. Ghobadi, The First International & 11th Iran Biophysical Chemistry
Conference, 13‐15 June 2012, Ardabil University of Medical Sciences,
Ardabil, Iran.
26. Comparative Evaluation of Sildenafil Effects on the Structure and Activity of
Native and Modified States of Human Carbonic Anhydrase II, R.
Khodarahmi, N. Bijari, S. A. Ghadami, S. Ghobadi, The First International &
11th Iran Biophysical Chemistry Conference, 13‐15 June 2012, Ardabil
University of Medical Sciences, Ardabil, Iran.
25. Purification of Lipid‐Transfer Protein‐1 (LTP‐1) from Rice Grain and Study
of Drug Binding to Normal and Modified LTPs, R. Khodarahmi, Sh.
Maghsoudi, M. R. Ashrafi, S. A. Ghadami, S. Ghobadi, M. Hamzeh The First
International & 11th Iran Biophysical Chemistry Conference, 13‐15 June
2012, Ardabil University of Medical Sciences, Ardabil, Iran.
24. Prediction of Aggregation Propensity and Amyloidogenic Regions in
Proteins, Based on Their Primary Sequences, R. Khodarahmi, S. A.
Ghadami, S. Ghobadi, The First International & 11th Iran Biophysical
Chemistry Conference, 13‐15 June 2012, Ardabil University of Medical
Sciences, Ardabil, Iran.
23. Fibrillar, Protein Aggregation May be Detrimental Via Different Oxidative
Routes: Relevance to the Etiology of Amyloid‐Related Neurodegenerative
Disorders Using the Experimental‐Based Evidences, R. Khodarahmi, Z.
Hosseinpour, S. Ghobadi, K. Mansouri, A. Mostafaie, Kh. Yari, S. A. Ghadami,
The First International & 11th Iran Biophysical Chemistry Conference, 13‐
15 June 2012, Ardabil University of Medical Sciences, Ardabil, Iran.
22. Comparative Studies on Drug Binding Characteristics and Protein Surface
Hydrophobicity of Native and Modified forms of Bovine Serum Albumin:
Possible Relevance to Change in Protein Structure Upon Glycation, R.
Khodarahmi, S.A. Karimi, M. R. Ashrafi, S. A. Ghadami, S. Ghobadi , M.
Amani, The First International & 11th Iran Biophysical Chemistry
Conference, 13‐15 June 2012, Ardabil University of Medical Sciences,
Ardabil, Iran.
21. Comparative Studies on PSH, Drug Binding Characteristics and
Conformational Stability of Native and Modified Forms of Bovine Serum
Albumin, R. Khodarahmi, S.A. Karimi, M. R. Ashrafi, S. A. Ghadami, S.
Ghobadi, M. Amani, The First International & 11th Iran Biophysical
Chemistry Conference, 13‐15 June 2012, Ardabil University of Medical
Sciences, Ardabil, Iran.
20. Aqueous extract of shallot (Allium ascalonicum) can abolish in vitro
angiogenesis through inhibition of vascular endothelial growth factor
(VEGF) and matrix metalloproteinases 2 and 9 (MMP‐2,9), D. Arshadi, K.
Mansouri, P. Seify, Y. Shakiba, R. Khodarahmi, A. Mostafaie, Inflammation
Research, 2011, 60, 199‐199
19. Comparative study on the formation of amyloid fibrils in the native and
modified β‐lactoglobulins, S. A. Ghadami, Moosa Ghasemi, R. khodarahmi,
S. Ghobadi 11th Iranian Congress of Biochemistry and Molecular Biology,
Qazvin University of Medical Sciences, 7‐9 Feb 2011, Qazvin, Iran.
18. Study of the interaction between furosemide and human carbonic
anhydrase II by spectroscopic methods, S. Ranjbar, S. Ghobadi, R.
Khodarahmi, FEBS Journal, 2010, 277, 184‐184
17. Formation of Amyloid Fibril Aggregation by ?‐Crystallin: Characterization of
Non‐Specific Peroxidase Activity of "Heme‐Aggregate" Complex in the
Presence of Various Substrates, Z. Hossein‐Pour, R. Khodarahmi, S.
Ghobadi, A. Mostafaie 16th and 4th International Conference of Biology,
Ferdowsi University of Mashhad, 14‐16 Sep 2010, Mashhad, Iran.
16. RBC Distruption and SK‐N‐MC Cell Toxicity in the Presence of ?‐Crystallin/
?‐Chymotrypsin Derived Amyloid Fibrils: The Ambiguous Effect of Heme, R.
Khodarahmi, Z. Hossein‐Pour, K. Mansouri, S.Ghobadi, F. Ahmadi 16th and
4th International Conference of Biology, Ferdowsi University of Mashhad,
14‐16 Sep 2010, Mashhad, Iran.
15. Spectroscopic Study of Interaction between Topiramate and Human
Cabonic Anhydrase II, M.R. Ashrafi, S. Ghobadi, R. Khodarahmi 16th and
4th International Conference of Biology, Ferdowsi University of Mashhad,
14‐16 Sep 2010, Mashhad, Iran.
14. Spectroscopic Study on the Interaction of Celecoxib with Human Carbonic
Anhydrase II: Thermodynamic Characterization of the Binding Process, M.
Mehrabi, R. Khodarahmi, S. Ghobadi, , 10th Iranian Congress of
Biochemistry & 3rd International Congress of Biochemistry and Molecular
Biology, 16‐19 Nov 2009, Tehran, Iran.
13. Irreversible Thermal Denaturation of Human Carbonic Anhydrase, M.
Amani, R. Khodarahmi, M. Mehrabi, S. Ghobadi, A. A. Moosavi‐
Movahedi,10th Iranian Congress of Biochemistry & 3rd International
Congress of Biochemistry and Molecular Biology, 16‐19 Nov 2009, Tehran,
Iran.
12. Fluorimetric study of the assisted renaturation of carbonic anhydrase, R.
Khodarahmi and R. Yazdanparast, 8th Iranian congress of Biochemistry and
First international congress of Biochemistry and molecular Biology,
September 11‐15, 2005.
11. Comparative evaluation of the artificial chaperone‐assisted renaturation of
carbonic anhydrase using β‐cyclodextrin and ionic detergents, R. Khodarahmi
and R. Yazdanparast , 30th FEBS congress and 9th IUBMB conference, Budapest,
Hungary, 2‐7 July, 2005.
10. Glycerol as folding aid and aggregation suppressor of denatured α‐amylase, F.
Khodagholi, R. Khodarahmi and R. Yazdanparast, 12th Iranian Congress of
Biology, Hamedan, Iran, Sep. 1‐3, 2004.
9. Quantitative evaluation o chaperone‐like activity of calcium ion based on
suppression of α‐amylase aggregation, R. Khodarahmi and R. Yazdanparast,
12th Iranian Congress of Biology, Hamedan, Iran, Sep. 1‐3, 2004.
8. The effects of Calcium and α‐CD on the renaturation yield and aggregation
extent of denatured α‐amylase, R. Yazdanparast and R. Khodarahmi, , 5th
international congress on Biochemistry and Chemical Engineering, Havana,
Cuba, Oct. 18‐22, 2004.
7. Effect of guanidine hydrochloride concentration on the α‐CD‐induced
renaturation of denatured α‐amylase, R. Khodarahmi and R. Yazdanparast,
5th international congress on Biochemistry and Chemical Engineering,
Havana, Cuba, Oct. 18‐22, 2004.
6. Study of dilution factor and protein concentration effects on the yield of
artificial chaperone‐assisted refolding of α‐amylase, F. Khodagholi, R.
Khodarahmi and R. Yazdanparast, The 17th FAOBMB Symposium / 2nd IUBMB
Special Meeting / 7th A‐IMBN Conference on “Genomics and Health in the 21st
Century”, Bangkok, Thailand, November, 22‐26, 2004.
5. Artificial chaperone‐assisted refolding of denatured α‐amylase using β‐
cyclodextrin, R. Khodarahmi, R. Yazdanparast and F. Khodagholi, The 17th
FAOBMB Symposium / 2nd IUBMB Special Meeting / 7th A‐IMBN Conference on
“Genomics and Health in the 21st Century”, Bangkok, Thailand, November, 22‐
26, 2004.
4. Purification and characterization of Lumbricus Terrestris (Earth Worm)
extracellular giant hemoglobin and its perspective as a ligand for affinity
chromatography, Hamid Rahi and R.Khodarahmi, 6th Iranian Biophysical
chemistry Conference, Damghan, Iran, 7‐9 September, 2004.
3. Importance of α‐cyclodextrin (α‐CD) central cavity in control of aggregation and
refolding yield of α‐amylase, R. Khodarahmi and R. Yazdanparast, 10th
Congress of the Federation of Asian and Oceanic Biochemists and Molecular
Biologists (FAOBMB), Bangalore, India, December 7‐11, 2003.
2. The effect of Calcium ion on the extent of refolding and aggregation of
denatured α‐amylase, R. Khodarahmi and R. Yazdanparast, 7th Congress
of Biochemistry, Ahvaz University of Medical Sciences, Ahvaz, Iran, 26‐29
Jan 2004.
1. Rapid purification of human Chorionic Gonadotropin (hCG) using Hb‐
Sepharose, H. Rahi and R. Khodarahmi, 5th Iranian Congress of Biology,
University of Tehran, Tehran, Iran, 15‐18 Aug 2001.